| Authors | Falcone C, Emanuele E, D'Angelo A, Buzzi MP, Belvito C, Cuccia M, Geroldi D. | |
| Title | Plasma
levels of soluble receptor for advanced glycation end products and coronary
artery disease in nondiabetic men. |
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| Full source | Arterioscler Thromb Vasc Biol. 2005 May;25(5):1032-7 | |
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 Per scorrere le diapositive |
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| Abstract | OBJECTIVE:
The receptor for advanced glycation end products (RAGE) is a cell surface
receptor whose signaling pathway has been implicated in atherogenesis. RAGE
has an endogenous secretory receptor form, called soluble RAGE (sRAGE),
that could exert antiatherogenic effects by acting as a decoy. We sought
to determine whether a decreased plasma level of sRAGE could be independently
associated with the prevalence of coronary artery disease (CAD) in nondiabetic
men. METHODS AND RESULTS: Plasma levels of sRAGE were determined in 328 nondiabetic male patients with angiographically proved CAD and in 328 age-matched healthy controls. The concentration of sRAGE in plasma was significantly lower (P<0.0001) in CAD cases [median (interquartile range): 966 (658-1372) pg/mL] than in control subjects [1335 (936-1954) pg/mL]. In logistic regression analysis, the multivariate-adjusted odds ratio for the presence of CAD was 6.719 (95% confidence interval, 3.773 to 11.964; P<0.0001) when the lowest quartile of the sRAGE level was compared with the highest quartile. CONCLUSIONS: Our findings indicate that low levels of sRAGE in plasma are independently associated with the presence of CAD in nondiabetic men and suggest that sRAGE is one of the clinically important molecules associated with atherosclerosis. |
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